Expert Consensus Guidelines™

Treatment of Epilepsy

Over the past decade, many new epilepsy treatments have been approved in the United States, promising better quality of life for many with epilepsy. However, clinicians must now choose among a growing number of treatment options and possible combinations. Unfortunately, randomized clinical trials rarely compare active therapies, making choices between different treatments difficult. Based on a survey of 45 experts on the treatment of epilepsy, these Expert Consensus Guidelines™ address a number of key questions concerning the treatment of epilepsy that are not adequately answered by the literature. Guidelines are presented for three epilepsy syndromes (idiopathic generalized epilepsy, symptomatic localization-related epilepsy, and symptomatic generalized epilepsy) and for status epilepticus. For each epilepsy syndrome and for status epilepticus, treatment algorithms are provided that outline overall strategies; guidelines also cover selection of specific medications and the use of combination therapies. Recommendations are also included on special issues such as the treatment of a woman in her reproductive years who is not pregnant and trying to conceive, of a woman who is pregnant or breastfeeding, of a medically stable elderly person, of a patient with clinical depression, and of a patient who is intellectually impaired.

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